Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth
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چکیده
منابع مشابه
Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth
Treatment for medulloblastoma, the most common malignant brain tumor in children, remains limited to surgical resection, radiation, and traditional chemotherapy; with long-term survival as low as 50-60% for Sonic Hedgehog (Shh)-type medulloblastoma. We have shown that the transcription factor Atonal homologue 1 (Atoh1) is required for Shh-type medulloblastoma development in mice. To determine w...
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ژورنال
عنوان ژورنال: eLife
سال: 2017
ISSN: 2050-084X
DOI: 10.7554/elife.31181